As herbal-based dietary supplement usage continues to increase, including among patients using prescription medicines, the potential for herb-drug interactions (HDIs) also increases. Patients and their physicians need more information on how botanical supplements could affect the safety and efficacy of drugs. Clinical studies are not always feasible, and conventional in vitro models have shown poor IVIVC.
Register for our webinar to learn more about a novel in vitro method to investigate HDIs that used sandwich-cultured human hepatocytes (SCHH), incorporated clearance, and treated the complex herbal mixture as a single entity.
Download the presentation to hear Dr. Amy Roe, Principal Toxicologist, The Procter and Gamble Company discuss:
- A physiologically-relevant model used to predict clinically-relevant HDIs. Study results were published in DMD Sep, 2017, “Prediction of Clinically Relevant Herb-Drug Clearance Interactions Using Sandwich-Cultured Human Hepatocytes: Schisandra spp. Case Study.”*
- Application of SCHH for studying the types of complex mixtures represented by herbal extracts.
- Application of the model approach to other complex mixtures and toxicity endpoints.
*This research was supported by P&G and conducted at BioIVT’s laboratory in Durham, NC.